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The main aim of the study was to determine the accuracy of a new test called pseudoparticle neutralization (pp NT), which can be used to detect antibody to MERS-Co V without the need for biosafety level-3 (BSL-3) containment.

The authors found that pp NT and microneutralization did not cross-react with antibodies to other coronaviruses found in camels, suggesting that they are good tools for seroepoidemiologic studies in animals.

Madani also told Reuters he didn't believe the non-reporting had been intentional and said he thought a 20% deficit in reporting of cases is not unusual in a disease outbreak. Osterholm is director of the University of Minnesota's Center for Infectious Disease Research and Policy, publisher of CIDRAP News."For serious outbreaks where cases are detected clinically and by labs, there should be complete ascertainment," he told CIDRAP News.

If a lab does confirm a case but doesn't report it, "that's a systems failure."He also noted that a large share of cases can go undetected and unreported if many people have only a mild illness or asymptomatic infections.

The case involves a 36-year-old male expatriate who is in stable condition in the southwestern town of Al Bahah. The case raised the Saudi MERS tally to 701 cases, while the death toll remained at 287.

Forty-six patients are still under treatment, and 368 have recovered.

The report appears to match up with limited information in a report that Qatar filed with the World Organization for Animal health (OIE) on Jun 9.The milk was collected according to local customs, with which, the authors say, contamination can easily occur.The serum samples and milk were tested for MERS-Co V antibodies, and the swabs and milk were tested for MERS-Co V RNA using reverse-transcription polymerase chain reaction (PCR).Osterholm said he'd like to see more information about all of Saudi Arabia's cases, but he described recent communication developments there as positive: "The information coming from Saudi Arabia right now is still not optimal; we still need more details on when, what, where, and how [patients] became infected.But I think they have a good start on improving on that, and I commend them for it."Meanwhile, a disclaimer posted today on the MOH's MERS-Co V page hinted that more surprises about case numbers could be on the way.

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